The current study investigates the antibacterial properties and plasmid-curing effects of Anacyclus pyrethrum extract in conjunction with Ginkgo biloba extract on Streptococcus mutans and other Streptococcus species in patients with dental caries and periodontitis. The antibacterial evaluation was performed utilising Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). While Ginkgo biloba extract necessitated 9 mg/mL to attain comparable results, Anacyclus pyrethrum extract achieved this at 8 mg/mL with S. mutans. The extract activation rate exceeded 81%. The experiment revealed that G. biloba required a dosage of 24 mg/mL, but A. pyrethrum necessitated 20 mg/mL to eradicate all the germs. Among all Streptococcus species, S. mutans demonstrated the most significant resistance to tetracycline and the least resistance to ciprofloxacin, while other Streptococcus species showed varying antibiotic resistances. The plasmid elimination assays revealed that the herbal extracts effectively eradicated plasmids in S. mutans, hence inhibiting plasmid replication and resulting in a diminished band intensity on plasmid staining compared to the ampicillin-treated samples. A. pyrethrum and G. biloba have shown their efficacy as anti-resistance therapeutic agents against oral infections owing to their antibacterial properties and plasmid-curing capabilities. The study demonstrates how these herbal extracts may serve as an alternative to conventional antibiotics in the natural treatment of tooth infections. They must possess clinical relevance, necessitating additional research involving actual individuals.