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REVIEW PAPER
Therapeutic Potential of Fabaceae-Derived Phytochemicals in Preventing Arterial Thrombosis: A Comprehensive Review
1
PG & Research Department of Zoology, Thiagarajar College, Madurai-09, affiliated to Madurai Kamaraj University, Madurai, Tamil Nadu, India
2
National Centre of Excellence in Statistical and Mathematical Modelling on Bio-Resource Management, Thiagarajar College, Madurai-09, affiliated to Madurai Kamaraj University, Madurai, Tamil Nadu, India
3
College of Fisheries and Marine Science, Partido State University, Nato, Sagñay, Camarines Sur,4421, Philippines, Philippines
Submission date: 2026-04-12
Final revision date: 2026-05-28
Acceptance date: 2026-06-10
Online publication date: 2026-07-28
Publication date: 2026-07-28
Corresponding author
Ashokkumar Sibiya
PG & Research Department of Zoology, Thiagarajar College, Madurai-09, affiliated to Madurai Kamaraj University, Madurai, Tamil Nadu, India
PG & Research Department of Zoology, Thiagarajar College, Madurai-09, affiliated to Madurai Kamaraj University, Madurai, Tamil Nadu, India
Journal of Medico Informatics 2026;02(Issue 03):9-20
HIGHLIGHTS
- Arterial thrombosis arises from endothelial injury, hypercoagulability, and stasis mechanisms.
- Fabaceae plants provide diverse phytochemicals with antiplatelet and anticoagulant potential.
- Flavonoids, tannins, saponins, and phenolics target multiple thrombotic pathways simultaneously.
- Dietary strategies support cardiovascular health and may reduce thrombotic risks.
- Computational approaches accelerate discovery of plant-derived antithrombotic agents.
KEYWORDS
TOPICS
ABSTRACT
Arterial thrombosis (ATh) has been conventionally observed in distinct circumstances, with alterations in risk factors, pathology and treatment since 17.5 million people got affected by cardiovascular diseases (CVDs) in 2012, with 31% of universal deaths annually. Blood coagulation is a vigorous functional process in the human body that is exaggerated by internal and external factors. Similarly, numerous inherited and acquired defects in the coagulation process are also the causative agent for several health-related problems in humans. Currently, many drugs have been approved and used for the treatment of arterial thrombosis but, those drugs are made of chemicals and result in serious health effects. As a result of problems associated with synthetic drugs, many researchers are focussing on alternative medication and looking for substitute treatments. Plants-based experimental studies have shown their significant role in the alternative treatment of thrombosis. Conversely, traditional medicinal plants-derived novel cardiovascular drugs can be used to prevent blood coagulation and treat ATh through various mechanisms. Recently, a wide range of medicinal plants from the family of Fabaceae were used enormously as antithrombotic agents due to their powerful antithrombotic activity. The current review focuses on ATh and its risk factors, diet and prevention methods using medicinal plants from the family Fabaceae and discovering their latent use in the progress of novel multifunctional medications against thrombosis.
ABBREVIATIONS
ACE: Angiotensin-Converting Enzyme
ADMET: Absorption, Distribution, Metabolism, Excretion and Toxicity
ADP: Adenosine Diphosphate
AI: Artificial Intelligence
AT: Arterial Thrombosis
BP: Blood Pressure
CVD: Cardiovascular Disease
DASH: Dietary Approaches to Stop Hypertension
DVT: Deep Vein Thrombosis
eNOS: Endothelial Nitric Oxide Synthase
GP: Glycoprotein
GPVI: Glycoprotein VI
HRT: Hormone Replacement Therapy
ICAM-1: Intercellular Adhesion Molecule-1
LDL: Low-Density Lipoprotein
MI: Myocardial Infarction
MUFA: Monounsaturated Fatty Acids
NO: Nitric Oxide
OC: Oral Contraceptive
PAI-1: Plasminogen Activator Inhibitor-1
PAR-1: Protease-Activated Receptor-1
PE: Pulmonary Embolism
PI3K: Phosphoinositide 3-Kinase
PLCγ2: Phospholipase C Gamma 2
P2Y12: P2Y Purinoceptor 12
PUFA: Polyunsaturated Fatty Acids
RBC: Red Blood Cell
ROS: Reactive Oxygen Species
SFA: Saturated Fatty Acids
TFA: Trans Fatty Acids
TP: Thromboxane Prostanoid Receptor
tPA: Tissue Plasminogen Activator
TXA₂: Thromboxane A₂
uPA: Urokinase-Type Plasminogen Activator
VCAM-1: Vascular Cell Adhesion Molecule-1
VTE: Venous Thromboembolism
VWF: von Willebrand Factor
ACKNOWLEDGEMENTS
The author thanks and acknowledge the Management of Thiagarajar College, Madurai for providing necessary facility.
FUNDING
This research received no external funding. All work was conducted using institutional resources without dedicated grant support.
CONFLICT OF INTEREST
The authors declare that they have no known financial, personal, academic, or other relationships that could inappropriately influence, or be perceived to influence, the work reported in this manuscript. The authors confirm that there are no competing interests to declare.
PEER REVIEW INFORMATION
Article has been screened for originality
© 2026 The Author(s). This article is distributed under the terms of the Creative Commons Attribution License (CC BY 4.0).
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